Intravitreal vancomycin and gentamicin concentrations in patients with postoperative endophthalmitis
نویسندگان
چکیده
منابع مشابه
Intravitreal vancomycin and gentamicin concentrations in patients with postoperative endophthalmitis.
BACKGROUND/AIMS To study the intravitreal antibiotic concentrations and the efficacy of an intravitreal dosing regimen to treat patients with postoperative bacterial endophthalmitis. This regimen, based on pharmacokinetic/pharmacodynamic considerations, relies on a repeat antibiotic injection of a lower dose than is generally used. METHODS In consecutive patients with suspected postoperative ...
متن کاملIntravitreal dexamethasone effect on intravitreal vancomycin elimination in endophthalmitis.
OBJECTIVE To determine whether intravitreal dexamethasone administration can alter the elimination of intravitreal vancomycin hydrochloride in rabbit eyes with experimental Streptococcus pneumoniae endophthalmitis. METHODS Albino rabbits were infected with an intravitreal inoculum of S pneumoniae (2 x 10(3) colony-forming units) and randomized after 24 hours to treatment with intravitreal van...
متن کاملVancomycin concentration in the vitreous after intravenous and intravitreal administration for postoperative endophthalmitis.
OBJECTIVES To measure the concentrations of vancomycin in the vitreous of patients with postoperative endophthalmitis after administration of 1 g of vancomycin hydrochloride intravenously and injection of 1 mg of vancomycin hydrochloride into the vitreous, and to determine whether these concentrations are adequate for treatment of gram-positive infections. METHODS Patients with acute postoper...
متن کاملIntravitreal Daptomycin for Recalcitrant Postoperative Endophthalmitis
PURPOSE To report the first case to our knowledge of intravitreal daptomycin used to successfully treat culture-negative vancomycin resistant to exogenous endophthalmitis. METHODS Case report with preoperative, intraoperative, and postoperative findings. RESULTS A 63-year-old Caucasian male underwent routine pars plana vitrectomy with epiretinal membrane peeling. He developed acute postoper...
متن کاملTreatment of experimental methicillin-resistant Staphylococcus epidermidis endophthalmitis with intravitreal vancomycin and intravitreal dexamethasone.
The use of intravitreal steroids to treat bacterial endophthalmitis remains controversial. The efficacy of intravitreal vancomycin alone (group 1), intravitreal dexamethasone alone (group 2), and a combination of intravitreal vancomycin and dexamethasone (group 3) in the treatment of experimental methicillin-resistant Staphylococcus epidermidis endophthalmitis was evaluated in a rabbit model: 2...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2001
ISSN: 0007-1161
DOI: 10.1136/bjo.85.11.1289